Du Hong-guang
2011
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0
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Journal
Chinese Journal of Synthetic Chemistry
Abstract
The key intermediate of preparing Granisetron hydrochloride,endo-9-methyl-9-azabicyclononan-3-amine(endo-1),was synthesized by oxidation of citric acid,then by the Mannich reaction,synthesis of Oxime,LiAlH4 reduction and the separation of endo-and exo-products in total yield over 16.8%.The structure was confirmed by IR,NMR and MS.