Wang Jie
2013
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Journal
Chinese Journal of Synthetic Chemistry
Abstract
Linezolid was synthesized from 3,4-difluoronitrobenzene by a six-step reaction of nucleophilic substitution,catalytic hydrogenation,N-protection,cyclization,N-deprotection and acetylation in overall yield of 69%.The structure was confirmed by 1H NMR,MS and IR.