Zhang Zhen-min
2014
Citations
0
Influential Citations
0
Citations
Journal
Chinese Journal of Synthetic Chemistry
Abstract
2-Methylthiopyridine( 2) was obtained by reaction of 2-chloropyridine and sodium methylmercaptide using polyethylene glycol 400 as the phase transfer catalyst. 2-Pyridyl tribromomethyl sulfone( 3) was synthesized by oxdation and bromination reaction of 2. The structures were confirmed by 1H NMR,IR and elemental analysis. The optimum reaction conditions at 80 ℃ for 4 h of synthesizing 2 were as followes: 1 was 100 mmol,sodium methylmercaptide was 0. 12 mol,and PEG-400( 1. 2 mL) was the catalyst,the yield was 98%. The optimum reaction conditions at 8 ℃ for 5 h of synthesizing 3 were as followes: 2 was 95 mmol,n( 2) ∶ n( bromine) = 1. 00 ∶ 6. 58,the yield was 99. 6% and the purity was 95. 1%.