Liu An-chan
2015
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Journal
Journal of Wuhan Institute of Technology
Abstract
3,5-Bis-(trifluoromethyl)benzene was nitrated by a fuming nitric-sulfuric acid, and then reduced with iron powder and hydrochloric to the 3,5-bis-(trifluoromethy)-aniline. 3,5-bis-(trifluoromethy)-aniline was chlorinated by chloride gas to give 2-chloro-3,5-bis-(trifluoromethyl)aniline. 2,6-Difluorobenzamide was synthesized from 2,6-difluorobenzonitrile via hydrolysis with solution of 30% hydrogen peroxide and 5%sodium hydrate,Then it reacted with oxalyl chloride in the solution of dichloro ethane to give the 2,6-difluorobenzoyl isocyanate. The title compound bistrifluron which exhibited potent growth-retarding activity against pests were prepared by treatment of 2,6-difluorobenzoyl isocyanate with 2-chloro-3,5-bis(trifluoromethyl)aniline in toluene and its yield is 93.5%. Finally, the bistrifluron was identified by1H-NMR. This process is feasible for industrial production.