Yan Na
2014
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Journal
Journal of Jiangxi Normal University
Abstract
The method for the synthesis of Viread was studied. The target product was synthesized from adenine via ring-opening condensation with( R)-propylene carbonate,etherification and ultrasonic radiation-assisted hydrolysis to give Tenofovir. Which was subjected to reaction with Iodine methyl isopropyl carbonate,followed by salt formation with an overall yield of about 31%,the HPLC purity was up to 99. 5%. The optimized synthetic process has the advantages of cheapness,high yield,simple and easy work-up. Which was more suitable for industrialized production.