Xu Zhen-yuan
2013
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Zhejiang Chemical Industry
Abstract
(E)-2-[2-(6-chloropyrimidin-4-yloxy) phenyl]-3-methoxyacrylate is synthesized from 3-(?methoxy) methylene benzofurans-2-(3H)-one,4,6-dichloropyrimidine and methanol in the presence of strong base by one-pot reaction.The synthetic route were studied and improved.The optimal reaction conditions were determined by and the total yield of 83% was obtained.The improved synthetic process is simple and safe,producing little industrial waste,which is suitable for industrial production.