Gong Ping
2007
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Journal
Chinese Journal of Medicinal Chemistry
Abstract
Aim To synthesize 2-[(pyridine-4-yl)methylamino]-N-[4-(trifluoromethyl)phenyl]benzamide(Ⅰ).Methods The title compound Ⅰ was synthesized from 2-nitrobenzoic acid via chlorination,aminolysis,hydrazine hydrate reduction,condensation,and sodium borohydride reduction added up to five steps.Results and conclusion The title compound Ⅰ was synthesized via five steps and its chemical structure was confirmed by 1H-NMR and MS.The improved process is more practical owing to its advantages of mild conditions,convenient operations and good yield of 54.5%.