Wen-yi Mei, Sen Yao, Ming-jun Yu
Jan 18, 2018
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Journal
Research on Chemical Intermediates
Abstract
A new and environmental friendly nitration process of methyl 3-methylbenzoate by mixtures of HNO3/Ac2O for the synthesis of 5-methyl-2-nitrobenzoic acid has been developed. In this strategy, the key process is the nitration of methyl 3-methylbenzoate. The main advantages of this procedure are that it utilized a high selectivity of substrates and a green nitrating process. This made control of the reaction rate much easier.