Luis D. Fuenmayor, M. Vogt
Sep 1, 1979
Citations
0
Influential Citations
18
Citations
Quality indicators
Journal
British Journal of Pharmacology
Abstract
1 The cataleptic and monoamine‐depleting effects of a butyrophenone derivative (4′‐fluoro‐4‐[[4‐(p‐fluorophenyl)‐3‐cyclohexen‐l‐yl]‐amino]‐butyrophenone hydrochloride, U‐32, 802A) were studied in rats and mice and compared with those of tetrabenazine. 2 Catalepsy was evaluated by means of a modified grid test which allowed the repetition of the test in the same animal several times without affecting the results. Both drugs produced a dose‐related cataleptic state of similar time course. 3 Like tetrabenazine, U‐32, 802A induced a large reduction in the content of 5‐hydroxytryptamine, dopamine and noradrenaline in different parts of the brain, with a concomitant elevation in the metabolites 5‐hydroxyindol‐3‐yl acetic acid and homovanillic acid. The time courses of the catalepsy and the reduction in brain monoamines were very similar. 4 The activity of U‐32, 802A suggested that the drug, although chemically a butyrophenone, might act primarily at the presynaptic organelle for storage of monoamines in a way similar to tetrabenazine.