Toshio Suzuki, H. Idogaki, N. Kasai
Nov 5, 1996
Citations
0
Influential Citations
5
Citations
Journal
Bioorganic & Medicinal Chemistry Letters
Abstract
Abstract A new production procedure of ( S )-4-chloro-3-hydroxybutyronitrile was developed using microbial resolution. The resting cells of Pseudomonas sp. OS-K-29 preferentially converted ( R )-4-chloro-3-hydroxybutyronitrile to the corresponding 1,2-diol by the dehalogenating activity so that ( S )-4-chloro-3-hydroxybutyronitrile (94.5 %ee) was obtained from the racemate in 40 % yield at the microbial resolution step.