X. Xue, Cheng-hai Su
Sep 25, 2010
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Abstract
The main ingredient of 99Tc-methylenediphosphonate(99Tc-MDP )is chelates which formed by the technetium 99Tc after stannous reduction and methylenediphosphonate. Studies have shown that 99TcMDP can inhibit the inflammatory response, play anti-inflammatory, anti-rheumatic effect, it also have significant analgesic effect by inhibit prostaglandin synthesis. In addition,99Tc-MDP also can regulate the body' s own immune and bone metabolism to treat the corresponding diseases. Treating rheumatoid arthritis,ankylosing spondylitis, Graves' ophthalmopathy and other autoinunne diseases. It also has a good effect on pain which is caused by cancer, femoral head necrosis and osteoporosis. Review progress of 99Tc-MDP in clinical applications. Key words: Arthritis, rheumatoid; Spondylitis, ankylosing; Grave ophthalmopathy; 99Tc-methylenediphosphonate