R. Pal
Dec 16, 2014
Citations
0
Influential Citations
2
Citations
Journal
ChemInform
Abstract
The role of commercially available Ammonium chloride in organic synthesis can not be understated. This review summarizes the versatile synthetic applications of Ammonium chloride in different chemical transformations. Reactions include Claisen rearrangement, Ullmann coupling, thia-Michael addition, three- component synthesis of dihydropyrimidinones, imidazo(1,2-a)pyridines, tetrahydrobenzo(a)xanthene-11-ones, benzoxazines, iminooxazolines, imidazo(1,2-a)pyrimidines, spirochromenes, spiroacridines, four-component synthesis of dipeptides, pyrrolo(3,4-b)pyridine-5-ones, crossed-aldol condensation, condensation of carbonyl compounds and indoles, synthesis of quinoxalines, arylbenzothiazoles, bisbenzothiazoles, reduction, and oxidation. Application of this catalyst allows mild and highly selective transformation and synthesis in a facile and environmentally friendly manner. Moreover, Ammonium chloride is an inexpensive and easily available catalyst, which acts under neutral conditons.