Xiaohua Sun, Chuan-ce Sun, Lijun Feng
2020
Citations
0
Influential Citations
0
Citations
Journal
Chinese Journal of Organic Chemistry
Abstract
Thieno[2,3- d ]pyrimidine compounds are an important class of organic synthesis intermediates and pharmacologi-cally active molecules, which not only have broad medical application prospect, but also worth researching. Therefore the synthesis of them has attracted much attention. The previous methods mainly apply tandem cyclization or one-pot multi-com-ponent reaction combined with microwave-assisted reaction or new catalysts to reach the purpose of shortening reaction time, reducing steps, enhancing yields and lowering costs. In this paper, the recent progress in the synthesis of thieno[2,3- d ]pyri-midine compounds via tandem cyclization in recent ten years, especially in the latest five years, is reviewed. The problems and limitations faced are discussed, and the development directions are also prospected.