Wang Xing-lin
2012
Citations
0
Influential Citations
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Citations
Journal
Chinese Journal of New Drugs
Abstract
Vincristine sulfate is an effective antineoplastic medicine.Due to neurological toxicity,its clinical application is restricted.As drug delivery system,liposomes can prolong the circulation time of many drugs,increase drug accumulation at disease site,improve therapeutic activity and reduce toxic effects.Formulations of vincristine using liposomes as carriers can improve the therapeutic outcome index.In this article,the influences of formulation composition and production process on the stability,pharmacokinetics and pharmacodynamics of vincristine sulfate liposomes were reviewed.The current advance of novel vincristine sulfate liposomes and the clinical research status were also reviewed.