Zhao Guo-qiang
2010
Citations
0
Influential Citations
4
Citations
Quality indicators
Journal
Chinese Journal of Pathophysiology
Abstract
AIM:To explore the effect of xanthosine(Xs) on proliferation and differentiation of bone marrow mesenchymal stem cells(BMSCs).METHODS: Xs was directly added to the culture system and the effects of Xs on proliferation and differentiation of BMSCs were observed.RESULTS: In the presence of Xs,the growth rate of the 10th passage cells was almost similar to that of the 4th passage cells and no downtrend was observed.However,in control group(without Xs),the growth rate of the 10th passage cells was obviously declined.The BMSCs promoted by Xs still kept up a vigorous capability of differentiation into hepatocytes.CONCLUSION: As an inhibitor of asymmetric cell kinetics,Xs can promote the conversion of BMSCs from asymmetric cell kinetics to symmetric cell kinetics,and keeps synchronously the ability of differentiation from BMSCs into hepatocytes as well.It is helpful for enhancing the proliferation efficiency of BMSCs in vitro,and will have extensive application of clinical practice.