Lei Yu, J. Luan, Lin Xu
Oct 28, 2015
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0
Influential Citations
12
Citations
Journal
Tetrahedron Letters
Abstract
Abstract Using l -proline catalyst, the useful building blocks 2-methylenecyclobutanones (2-MCBones) are now easily accessible in moderate to good yields through the condensation of the commercially available cyclobutanone with the abundant aldehydes. Compared with the literature reports, this methodology provides a direct synthesis of 2-MCBones from accessible starting materials and employs near neutral catalysts, which are stable to the acidic impurities in substrates.