A. Córdova, W. Notz, C. Barbas
Jan 11, 2002
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191
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Journal
The Journal of organic chemistry
Abstract
For the first time, the L-proline-catalyzed direct asymmetric self-aldolization of acetaldehyde is described affording (+)-(5S)-hydroxy-(2E)-hexenal 2 with ee's ranging from 57 to 90%. Further transformations of 2 into synthetically valuable building blocks are presented. A mechanism for the formation of 2 is proposed.