Xiantao Ma, Jing Yu, R. Yan
Aug 8, 2019
Citations
0
Influential Citations
13
Citations
Journal
The Journal of organic chemistry
Abstract
It is observed the crystal water in sodium thiosulfate pentahydrate (Na2S2O3•5H2O) can promote its multi-component reaction with heteroaryl chlorides and alcohols, providing a facile, green and specific synthesis of unsymmetrical heteroaryl thioethers via one-step formation of two C-S bonds under catalyst-, additive-, and solvent-free conditions. Mechanistic studies suggest that the crystal water in Na2S2O3•5H2O is crucial in generating the key thiol intermediates and byproduct NaHSO4, which then catalyzes the dehydrative substitution of alcohols with thiols to afford thioethers.