H. Collier, G. Chesher
Mar 1, 1956
Citations
0
Influential Citations
4
Citations
Journal
British journal of pharmacology and chemotherapy
Abstract
4-Hydroxyisophthalic acid (4-HIPA) was first described by Barth (1872). Idris Jones and his co-workers (Reports of Chemistry Research Board, 1952, 1953) identified 4-HIPA as the main constituent of the "brown dust" residues from the sublimation of salicylic acid during manufacture. They suggested that 4-HIPA should be examined for similar pharmacological properties to salicylic acid and they provided material for this purpose. Pharmacological examination showed that this compound indeed possessed potent antipyretic and mild analgesic properties, which led us to examine also 2-hydroxyisophthalic acid (2-HIPA), another by-product of the KolbeSchmitt process for the manufacture of salicylic acid. The results have been briefly reported (Chesher, Collier, Robinson, Taylor, Hunt, Idris Jones, and Lindsey, 1955). The present paper describes in detail the pharmacological work on both compounds.