R. Okamoto, M. Tsuchiya, H. Nomura
Nov 1, 1980
Citations
0
Influential Citations
32
Citations
Quality indicators
Journal
The Journal of antibiotics
Abstract
The antibacterial activity of acyl derivatives of tylosin were examined in vitro and in vivo. The 4"-acyl group in the acylated tylosins enhanced the antibacterial activity and antimycoplasmal activity against some macrolide-resistant strains. The orally administered 3-acetyl-4" -isovaleryltylosin produced a higher blood level in mice and rabbits than tylosin and a good therapeutic effect on the infection of Staphylococcus aureus Smith in mice.