Jack Fishman, C. Martucci
Sep 1, 1980
Citations
4
Influential Citations
210
Citations
Quality indicators
Journal
The Journal of clinical endocrinology and metabolism
Abstract
Metabolism of estradiol in men with cirrhosis and subjects with systemic lupus erythematosus results in an excessive formation of 16 alpha-hydroxyestrone. Examination of the biological activity of this metabolite showed that it is a potent uterotropic agent and that it exhibits minimal affinity for the human sex hormone-binding globulin. These biological characteristics are consistent with a hyperestrongenic response to the substance, which may be reflected in the pathology and etiology of these diseases.