O. Koshova, H. O. Ieryomina, L. Perekhoda
Dec 21, 2016
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Abstract
The study of the anti-allergic action of hydrobromide 2-[4-(41-chlorophenyl)-2-phenyliminothiazol- 3-yl]-ethanol under the code of 6.6 has been conducted. On the model of anaphylactic shock in guinea pigs it has been found that in the prophylactic administration in the dose of 5 mg/kg the test compound exhibits the anti-allergic activity at the level of the reference medicine “Claritin” tablets in the dose of 1 mg/kg – 65% and 76%, respectively. In “Ophthalmic response to introduction of histamine” test the compound studied showed the efficacy on average at the level of 72%, and the reference medicine – 83%. The data obtained allow assuming that the marked antihistaminic properties play an important role in the mechanism of the anti-allergic action of compound 6.6. The research conducted prove the reasonability of further pharmacological study of hydrobromide 2-[4-(41- chlorophenyl)-2-phenyliminothiazol- 3-yl]-ethanol with the aim of creating an effective anti-allergic medicine.