M. A. Spielman, R. K. Richards
1946
Citations
0
Influential Citations
0
Citations
Journal
Journal of the American Pharmaceutical Association. American Pharmaceutical Association
Abstract
Abstract A series of 1‐acyl‐3‐aminomethylureas has been synthesized by the condensation of acyl‐ureas with a secondary amine and formaldehyde. Only 1‐acetyl‐3‐piperidinomethylurea hydrochloride has a satisfactory analgesic effect. Clinical trial, however, brought out undesirable side effects. The drug is unstable in solution, and piperidine, the chief breakdown product, seems to be responsible for many of the pharmacological phenomena elicited.