Yang Yan, Liu Wanshun, Han Bao-qin
Jul 1, 2006
Citations
0
Influential Citations
28
Citations
Quality indicators
Journal
Nutrition Research
Abstract
Abstract A new 2-substituted thiazolidine-4(R)-carboxylic acid (TCA), 2-glucosamine-TCA (GlcNH 2 Cys), was synthesized with its antioxidative properties, compared with those of 2 other 2-substituted TCAs, 2-gluco-TCA and 2-galacto-TCA. The GlcNH 2 Cys showed antioxidative properties of scavenging reactive free radicals (hydroxyl radical and superoxide anion), preventing macromolecules damage (deoxyribose, protein, and lipid), and was hepatoprotective against acetaminophen-induced liver damage by replenishing sulfhydryl levels, increasing the total antioxidative capacity of the liver, and inhibiting lipid peroxidation. GlcNH 2 Cys is a promising compound to protect against oxidative stress xenobiotics.