V. Karthick, T. Selvam, Vijayaraj Kumar Palanirajan
Sep 1, 2016
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Quality indicators
Journal
Journal of Saudi Chemical Society
Abstract
Abstract In the present study, a series of novel 2-(substituted benzylidene)-7-(4-chlorophenyl)-5-(furan-2-yl)-2 H -thiazolo[3,2 -a ]pyrimidin-3(7 H )-one derivatives ( 4a – i ) were designed and synthesized to meet the structural requirements essential for antiepileptic activity. Antiepileptic screening was performed by maximal electroshock (MES) and subcutaneous pentylenetetrazole (s c PTZ) seizures tests and neurotoxicity was determined by the rotorod test. Among the synthesized compounds 4f , 4g and 4h were found active in both MES and sc PTZ models. In the view of results the most active compounds carry fluoro > chloro > bromo substituent’s at the para position in the phenyl ring. The chemical structures of the synthesized compounds were confirmed by means of IR, 1 H NMR, mass spectroscopy and elemental analysis.