P. Chabert, A. Fougerousse, R. Brouillard
2006
Citations
1
Influential Citations
31
Citations
Quality indicators
Journal
BioFactors
Abstract
(Z)‐3,5,4′‐Trimethoxystilbene is a natural polyphenol present in five different plants, Virola cuspidata, Virola elongata, Centipeda minima, Schoenus nigricans and Rheum undulatum. This molecule was prepared in a three‐step sequence in good overall yield. The isomerisation from the (E)‐ to (Z)‐isomer is performed using UV irradiation. Biological investigations were conducted on a human colon cancer cell line (Caco‐2) with anti‐mitotic activities. Growth was completely arrested at an added 0.4 μM level of (Z)‐3,5,4′‐trimethoxystilbene. This agent is 100‐fold more active than resveratrol or (E)‐3,5,4′‐trihydroxystilbene, and the mechanism of this process involves an inhibition of tubulin polymerisation in a dose dependent manner.