W. Bollag
Oct 1, 1975
Citations
1
Influential Citations
107
Citations
Quality indicators
Journal
European journal of cancer
Abstract
Abstract An aromatic analog of retinoic acid, ethyl all-trans- 9 -( 4 -methoxy- 2,3,6 -trimethylphenyl)- 3,7 -dimethyl- 2,4,6,8 -nonatetraenoate (= Ro 10-9359 ), has been found to possess a prophylactic effect on the development of skin papillomas and carcinomas of mice induced by 7,12 -dimethylbenzanthracene and croton oil. The daily oral application of 30 mg/kg Ro 10-9359 —given during the promotion phase of carcinogenesis-delayed the appearance and retarded the growth of papillomas and reduced the incidence of carcinomas. Considering the low toxicity of Ro 10-9359 , its preventive action on epithelial tumors is very remarkable.