Wen Xiujie, T. Kiang, Wufei Ji
2022
Citations
0
Influential Citations
0
Citations
Journal
Proceedings of the 11th International Conference on Biomedical Engineering and Bioinformatics
Abstract
: The proposed retrosynthesis of a guaianolide-type sesquiterpenoid. The first route begins with the construction of a 5,7,5-ring sesquiterpenoid through the connection α, β-cyclopentenone derivative from Pauson-Khand reaction and trans lactone by a special Barbier reagent. Firstly, angelic acid is used to complete the synthesis via esterification with enclosing central ring sesquiterpenoid. The second route starts with the fabrication of a modified trans configured lactone with methylene. A following Pauson-Khand reaction appends α, β-cyclopentenone on the lactone. Finally, angelic acid completes the synthesis by esterification with exterior hydroxy of sesquiterpenoid.