G. Sanger, A. Jackson, A. Bennett
Jun 16, 1982
Citations
0
Influential Citations
10
Citations
Quality indicators
Journal
European journal of pharmacology
Abstract
Abstract A prostaglandin analogue, (±)-5-(6-carboxyhexyl)-1-(3-cyclohexyl-3-hydroxypropyl) hydantoin was tested on strips of human isolated myometrium and gastro-intestinal muscle. The analogue usually caused marked dose-dependent myometrial relaxation and inhibition of spontaneous activity, with a threshold concentration sometimes of 10 pg/ml and a maximum effect at 10 ng/ml. In contrast 1–10 000 ng/ml had no effect on longitudinal muscle strips of human stomach or colon.