M. Xie, T. Widlanski
Jun 24, 1996
Citations
0
Influential Citations
20
Citations
Journal
Tetrahedron Letters
Abstract
Abstract The isobutyl ester proved to be a useful protecting group for the construction of sulfonate-containing analogs of nucleosides. The syntheses of useful uridine or adenosine 3′-C-methanesulfonate analogs 1a or 1b that fail when using ethyl or isopropyl sulfonate esters, are readily accomplished with the isobutyl ester as a protecting group. In addition, alkylation reactions to give homologated sulfonates such as 2 are also much more facile when using the isobutyl protecting group.