A. El Alaoui, Frédéric Schmidt, C. Monneret
Dec 1, 2006
Citations
0
Influential Citations
36
Citations
Journal
The Journal of organic chemistry
Abstract
To prepare two new glucuronide conjugates, allyl ester and allyl carbonates were used as protecting groups of the glucuronic moiety. In this way, an aniline glycosyl carbamate spacer linked to the 2'-OH of paclitaxel was obtained. By using palladium chemistry, an efficient one-step removal of all the allyl groups at the end of the synthesis afforded the desired compounds in good yields.