P. Sieber, B. Riniker
1987
Citations
1
Influential Citations
58
Citations
Journal
Tetrahedron Letters
Abstract
Abstract The trityl (Trt) group is ideally suited for the side-chain protection of His in peptide syntheses, in combination with 9-fluorenylmethyloxycarbonyl (Fmoc) in N α - and protecting groups cleavable by mild acidolysis in other positions of the peptide. 2,4,5-trichlorophenyl (Tcp)- and pentafluorophenyl (Pfp)-esters of Fmoc-His(Trt)-OH and Trt-His(Trt)-OH are strongly activated, but stable compounds. N α -Trt is selectively removable in the presence of N Im -Trt.