M. Chrominski, Keith ó Proinsias, E. Martin
Mar 1, 2013
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Influential Citations
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Journal
European journal of organic chemistry
Abstract
A new cobyrinate/protoporphyrin IX molecular hybrids were prepared via CuAAC reaction. The synthesis involved selective preparation of cobyrinate and PpIX derived building blocks possessing respectively terminal alkyne and azide moieties followed by the CuOAc catalyzed cycloaddition reaction. Synthesized molecules activated soluble guanylyl cyclase showing strong linker length/activation dependence.