N. Queiroz, M. G. Nascimento
Jul 22, 2002
Citations
0
Influential Citations
43
Citations
Journal
Tetrahedron Letters
Abstract
In the present report, we describe the preparative-scale resolution of (R,S)-methyl mandelate by acylation with vinyl acetate catalyzed by free Pseudomonas sp. lipase or immobilized in poly(ethylene) oxide (PEO) and agar gel, in organic media. Under experimental conditions the method was very effective using the enzyme immobilized in PEO. The degree of conversion was near 50% and yielded both enantiomers with practically 100% of optical purity.