J. Jacobs, Michèle Moris, Tim De Samber
Oct 1, 2016
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Acta crystallographica Section B, Structural science, crystal engineering and materials
Abstract
Crystallization of tacrine hydrochloride, an acetylcholinesterase inhibitor used during treatment of mild to moderate Alzheimer's disease, from a water:ethanol solution has resulted in an orthorhombic pseudopolymorph. This orthorhombic form which occurs as a dihydrate shows columns of stacking acridines together with continuous Cl-Owater-Owater-Cl chains and ladder-like ribbons composed of squares and hexagons.