Preeti Wadhwa, Tanpreet Kaur, Neetu Singh
2016
Citations
0
Influential Citations
17
Citations
Journal
Asian Journal of Organic Chemistry
Abstract
The first p-toluenesulfonic acid-mediated “on-water” multicomponent reaction sequence for the synthesis of novel thiadiazolo[2,3-b]quinazolinones from 5-aryl-1,3,4-thiadiazol-2-amines, cyclic 1,3-dicarbonyls and aldehydes with microwave irradiation is described. This protocol proceeds with high atom economy and leads to the generation of three rings, together with one C−C, one C=N and two C−N bonds in a single operation. This new methodology has advantages such as operational simplicity, mild conditions, broad functional group tolerance, simple work-up procedure and applicability on a gram scale.