R. Ananth, Jian Chen, W. Shum
Feb 1, 1995
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Influential Citations
3
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Journal
Tetrahedron-asymmetry
Abstract
Abstract The melting point phase diagrams of glycidyl tosylate ( 1 ), glycidyl 3-nitrobenzenesulfonate ( 2 ), and trans -3-methylglycidyl tosylate ( 3 ) have been investigated. Compounds 1 and 2 are found to exhibit a more significant solid solution behavior in the terminal zones of the phase diagram than 3 , and are therefore more difficult to enrich enantiomerically by recrystallizations. The crystallization of 2 in ethanol is further complicated by polymorphism which can be followed by differential scanning calorimetry. The effects of these properties on the optical purification of 1–3 are discussed.