T. A. Taktashkina, I. P. Zaitseva, S. B. Germanov
Nov 1, 1996
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Journal
Pharmaceutical Chemistry Journal
Abstract
Thionyl chloride is one of the most widely used reagents in fine organic synthesis and in the chemico-pharmaceutical industries for obtaining chloroarthydrides of various acids, chlorine substitution for hydroxy groups, and the synthesis of heterocyclic compounds. Some of these procedures impose very high requirements on the quality of reagents. For example, the production of isoxazole antibiotics requires that the thionyl chloride not contain more than 0.3% sulfuryl chloride and not more than 1.0% total of other impurities. Cheap and readily available commercial thionyl chloride of technical purity (Russian Technological Standard TU 113-00-38-I 16-91) contains up to 10% impurities and cannot be used without additional purification. Recommended purification methods based on the rectification process are technologically inconvenient because the reagent exhibits high corrosion activity and toxicity. Therefore, development of a new method for thionyl chloride purification that can be conveniently em-