A. Gulevskaya, A. Pozharskii, S. V. Shorshnev
Sep 1, 1994
Citations
0
Influential Citations
6
Citations
Journal
Chemistry of Heterocyclic Compounds
Abstract
Abstract1,3-Dimethylpyrimido[4,5-d]pyrimidine-2,4-(1H,3H)dione (l) reacts with alkylamides in liquid ammonia in the presence of an oxidizing agent such as KMnO4 or Ag(C5H5N)2MnO4, giving 7-amino derivatives; but the interaction of (1) with methylamine gives a mixture of isomeric alkylaminated products. Subsequent hydrolysis of the 7-piperidino derivatives in an alkaline medium and then in an article medium gives 4-methylamino-2-piperidinopyrimidine with quantitative yield.