A. Deeb, M. El-Abbasy
Apr 1, 2006
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Journal
Phosphorus, Sulfur, and Silicon and the Related Elements
Abstract
7-substituted pyrido[2′, 3′: 4, 5]thieno[2, 3-c]pyridazines and 6-substituted pyrimido- [4′, 5′: 4, 5]thieno[2′, 3′: 4, 5]pyridazines were synthesized starting from ethyl 5-aminothieno[2′, 3′: 4, 5]pyridazino-6-carboxylate 1. The reaction of amino ester 1 with benzoyl isothiocyanate affords thiourea derivative 8, which undergoes further transformation to the related fused heterocyclic systems.