E. Sotelo, N. Fraiz, M. Yáñez
Sep 1, 2002
Citations
1
Influential Citations
72
Citations
Quality indicators
Journal
Bioorganic & medicinal chemistry
Abstract
A series of 6-phenyl-3(2H)-pyridazinones with a diverse range of substituents in the 5-position have been prepared and evaluated in the search for new antiplatelet agents. A significant dependence of the substituent on the inhibitory effect has been observed. The pharmacological study of these compounds confirms that modification of the chemical group at position 5 of the 6-phenyl-3(2H)-pyridazinone system influences both variations in the antiplatelet activity and the mechanism of action.