B. Schober, G. Megyeri, T. Kappe
Mar 1, 1990
Citations
0
Influential Citations
13
Citations
Journal
Journal of Heterocyclic Chemistry
Abstract
The nucleophilic introduction of chloro- (2), azido- (4), (substituted) amino (3, 6), mercapto (10) and hydrazino-groups (13) into 2-aryl-5-hydroxypyridazin-3(2H)-ones [3] is described. The 5-aminopyridazin-3(2H)-one (6) also reacts with activated malonates 8 [4] to give pyrido[2,3-d]pyridazines 9. Hydrazino compounds 13 can be treated with aldehydes to yield compounds 14. Iodine can be introduced into position 4 of 5-amino-(15) and 5-hydroxypyridazin-3(2H)-ones (17) by electrophilic substitution to afford compounds 18.