M. Tajbakhsh, H. Alinezhad, Mohammad Norouzi
2013
Citations
0
Influential Citations
83
Citations
Quality indicators
Journal
Journal of Molecular Liquids
Abstract
Abstract The four-component Hantzsch condensation reaction of dimedone, ethyl acetoacetate, ammonium acetate and various aromatic and aliphatic aldehydes in the presence of 2-methylpyridinium trifluoromethanesulfonate ([2-MPyH]OTf) as a green and highly efficient catalyst in water affords polyhydroquinoline derivatives in good to excellent yields. This reaction has been carried out in the presence of 1 mol% of [2-MPyH]OTf at room temperature. The described novel synthesis method proposes several advantages of short reaction times, high yields, mild condition, high melting point, simplicity and easy workup compared to the traditional method of synthesis.