T. Okawa
Oct 1, 1998
Citations
0
Influential Citations
13
Citations
Journal
Synthesis
Abstract
: Pyrido[2,3-d ]pyrimidine derivatives 5 were synthesized by the intermolecular aza-Wittig reaction of 2-(triphenylphospho-ranylidene)aminonicotinamides 3 derived from 2-aminonicotinic acid (1) , with carboxylic acid chloride followed by heterocycliza-tion via imidoyl chloride intermediate 4 . The structure of 3-allyl- 2-(4-nitrophenyl)-4(3 H )-pyrido[2,3-d ]pyrimidinone (5b) was established by X-ray crystallographic analysis. This methodology has been applied also to a novel synthesis of 4(3 H )-quinazolinone 14 .