C. G. Dave, Killol J. Patel
Mar 1, 2001
Citations
0
Influential Citations
4
Citations
Journal
Journal of Heterocyclic Chemistry
Abstract
2-Thioxo-5,7-dimethylpyrido[2,3-d]pyrimidin-4(3H)-ones 3 were synthesized by the cyclocondensation of 2-amino-3-carbethoxy-4,6-dimethylpyridine 1 with methyl-N-aryldithiocarbamates 2 and compared with the condensation between 1 and aryl isothiocyanates 4. When a comparative study of N vs S alkylation of ambident 2-thioxo-5,7-dimethylpyrido[2,3-d]pyrimidin-4(3H)-ones 3 was carried out under liquid-liquid and solid-liquid phase transfer conditions using various alkylating agents 5, the S-alkylated products 6 were obtained exclusively and selectively.