T. Vutyavanich, Supreeya Wongtra‐ngan, Rung-Aroon Ruangsri
Sep 1, 1995
Citations
1
Influential Citations
140
Citations
Quality indicators
Journal
American journal of obstetrics and gynecology
Abstract
OBJECTIVE Our purpose was to determine the effectiveness of pyridoxine for nausea and vomiting of pregnancy. STUDY DESIGN During an 11-month period 342 women who first attended Chiang Mai University Hospital antenatal clinic at < or = 17 weeks' gestation were randomized to received either oral pyridoxine hydrochloride, 30 mg per day, or placebo in a double-blind fashion. Patients graded the severity of their nausea by a visual analog scale and recorded the number of vomiting episodes over the previous 24 hours before treatment and again during 5 consecutive days on treatment. RESULTS There was a significant decrease in the mean of posttherapy minus baseline nausea scores in the pyridoxine compared with that in the placebo group (t test, p = 0.0008). There was also a greater reduction in the mean number of vomiting episodes, but the differences did not reach statistical significance (p = 0.0552). CONCLUSION Pyridoxine is effective in relieving the severity of nausea in early pregnancy.