R. G. Melik-Ogandzhanyan, A. S. Gapoyan, V. E. Khachatryan
1982
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Journal
Chemistry of Heterocyclic Compounds
Abstract
A new scheme was developed for the synthesis of 2,4-dimethy1-5,6-dihydro-6-bromomethylthieno[2,3-d]pyrimidine by bromination of the corresponding 5-allyl-6-mercaptopyrimidine. It is shown that when the bromomethyl derivative is treated with sodium methoxide a molecule of hydrogen bromide is split out to give 2,4,6-trimethylthieno[2,3-d]pyrimidine. The structures of the synthesized compounds were proved by PMR spectroscopy and mass spectrometry.