S. D. de Laszlo, D. Visco, L. Agarwal
Oct 6, 1998
Citations
5
Influential Citations
97
Citations
Quality indicators
Journal
Bioorganic & medicinal chemistry letters
Abstract
Investigation of furans, pyrroles and pyrazolones identified 3-pyridyl-2,5-diaryl-pyrroles as potent, orally bioavailable inhibitors of p38 kinase. 3-(4-pyridyl-2-(4-fluoro-phenyl)-5-(4-methylsulfinylphenyl)-pyrrol e (L-167307) reduces secondary paw swelling in the rat adjuvant arthritis model: ID50 = 7.4 mg/kg/b.i.d.