E. B. Tsupak, M. Shevchenko, A. Pozharskii
Jul 1, 2003
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Influential Citations
6
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Journal
Chemistry of Heterocyclic Compounds
Abstract
The reaction of 6-amino-1,3-dimethylpyrrolo[3,4-d]pyrimidine-2,4-dione with 1,3-diketones leads to formation of predominantly pyrimido[4',5':3,4]pyrrolo[1,2-b]pyridazine-2,4(1H,3H)-diones and, to a lesser extent, pyrimido[5',4':3,4]pyrrolo[1,2-b]pyridazine-1,3(2H,4H)-diones. The ease and direction of the cyclization reaction suggests a very π-electron rich pyrrole ring in the initial state, especially in the position 7.