V. Agrawal, R. Sohgaura, P. Khadikar
Sep 1, 2002
Citations
1
Influential Citations
17
Citations
Journal
Bioorganic & medicinal chemistry
Abstract
Quantitative structure-activity relationship (QSAR) studies for 2,6-substituted 2,4-diaminopyrido[3,2-d] pyrimidine analogues of piritrexim (PTX) as inhibitors of dihydrofolate reductase (DHFR) are now made using topological indices. The results have shown that best models are obtained by multiparametric analysis. The predictive potential of the model is discussed on the basis of a cross-validation method.